PHP112 Inter-Individual Country Variability in Monoclonal Antibodies (MABS) Reimbursement and Coverage Following EMA Approval

Monoclonal Antibodies

SUMMARY Monoclonal Antibodies are identical antibodies and Can be generated in ultimated amounts by countinuos cultures of single antibody- secreting cells. These cell lines are produced by cell fusion of normal lymphocytes to cells of a myeloma tumor cell line, which confers on the antibody producing hybrid cell, immortality and the ability grow as atumor in animals. monoclonal antibodies c...

Children's Inter-Individual Variability and Asthma Development.

Children of different ages vary in their response to environmental stressors due to their continuous development and changes in their bodies' anatomy, physiology, and biochemistry. Each age group of children has special biological features that distinguish their toxicokinetic and toxicodynamic characteristics from other age groups. The variability in responses extends to include children of the...

Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population

Inter- and intra-individual variability in alpha peak frequency

Converging electrophysiological evidence suggests that the alpha rhythm plays an important and active role in cognitive processing. Here, we systematically studied variability in posterior alpha peak frequency both between and within subjects. We recorded brain activity using MEG in 51 healthy human subjects under three experimental conditions - rest, passive visual stimulation and an N-back wo...

Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics.

Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients attain suitable drug exposure to achieve efficacy and avoid toxicity. Inter-subject variability in the pharmacokinetics of therapeutic monoclonal antibodies (mAbs) is generally moderate to high; however, the factors responsible for the high inter-subject variability hav...